Are Your Organs Aging at Different Speeds?

Vero co-founder and CEO Paul Coletta joined Peter Bowes on Live Long for a wide-ranging conversation on organ-level aging, self-experimentation, and where the line sits between healthy optimization and over-testing.

Eleven organs, one blood draw

OrganAge reads a single vial of blood plasma against organ-specific proteomic models, returning a separate biological age for each of 11 organs rather than one blended score. Coletta pointed to the brain in particular as what he calls the "gateway organ" — the one with the broadest downstream influence on the rest of the body.

A kidney result that changed a daily habit

Coletta's own test flagged his kidney as his most accelerated organ. A follow-up ultrasound found a benign cyst — a finding that led him to reassess something as basic as his water intake, and adjust it. It's a small, concrete example of the thing Coletta and Bowes spend much of the episode circling: a result only matters if it changes what you actually do next.

Does measurement change behavior?

That question — whether simply measuring something is enough to drive real behavior change, or whether it takes more than a number on a screen — runs through the second half of the conversation, alongside Coletta's own self-experimentation with creatine, sunlight, and sleep.

"It's the quality of energy and vitality that I want to have. We are already living older." — Paul Coletta

Where the science stands

Coletta was direct about timelines: he expects broader availability sometime in late 2027 or early 2028, and was clear that clinical validation remains the priority before then — not a box to check after the fact.

Listen to the full conversation on YouTube, including Coletta's take on when health optimization goes too far, and his own daily longevity stack.